刘凯
博士,副教授,硕士生导师,神经生物学
1998年毕业于北京大学生命科学学院,获得理学学士学位。1998年至2006年就读于新泽西州立罗格斯大学,获得博士学位。2006年至2011年于在哈佛大学医学院波士顿儿童医院进行博士后研究工作。2011年获聘为香港科技大学助理教授,2017为香港科技大学副教授。现为深圳北京大学香港科技大学医学中心硕士生导师。主要研究方向为中枢神经系统轴突再生的机制。先后主持国家自然科学基金以及香港和深圳市科技计划10项。
代表性论文:
1. Park KK*, Liu K*, Hu Y*, Smith PD*, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science 2008 Nov 7;322(5903):963-6.
2. Shen Y, Tenney AP, Busch SA, Horn KP, Cuascut FX, Liu K, He Z, Silver J and Flanagan JG. PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science 2009 Oct 23;326(5952):592-6.
3. Liu K*, Lu Y*, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nature Neuroscience 2010 Sep;13(9):1075-81.
4. Liu K, Tedeschi A, Park KK, He Z. Neuronal intrinsic mechanisms of axon regeneration. Annual Review of Neuroscience 2011;34:131-52.
5. Li S*, He Q*, Wang H, Tang X, Ho KW, Gao X, Zhang Q, Shen Y, Cheung A, Wong F, Wong YH, Ip NY, Jiang L, Yung WH, Liu K. Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons. Neurobiology of Disease 2015 Jan;73:366-76. Epub 2014 Oct 16.
6. Fang WQ, Chen WW, Jiang L, Liu K, Yung WH, Fu AKY, Ip NY. Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice. Cell Reports 2014 Dec 11;9(5), 1635-1643.
7. Geoffroy CG, Lorenzana AO, Kwan JP, Lin K, Ghassemi O, Ma A, Xu N, Creger D, Liu K, He Z, Zheng B. Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice. Journal of Neuroscience 2015 Apr 22;35(16):6413-28.
8. Du K*, Zheng S*, Zhang Q*, Li S, Gao X, Wang J, Jiang L, Liu K. Pten deletion promotes regrowth of corticospinal tract axons 1 year after spinal cord injury. Journal of Neuroscience 2015 July 1;35(26): 9754-9763.
9. Shum JWH, Liu K, So KF. The progress in optic nerve regeneration, where are we? Neural Regeneration Research 2016 Jan; 11(1): 32–36.
10. Li S*, Yang C*, Zhang L, Gao X, Wang X, Liu W, Wang Y, Jiang S, Wong YH, Zhang Y, Liu K. Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling. Proceedings of the National Academy of Sciences 2016 Feb 16;113(7):1937-42.
11. Zeng M, Shang Y, Guo T, He Q, Yung WH, Liu K, Zhang M. A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function. Proceedings of the National Academy of Sciences 2016 May 31;113(22):E3081-90
12. Chen W, Lu N*, Ding Y*, Wang Y*, Chan LT, Wang X, Gao X, Jiang S, Liu K. Rapamycin-resistant mTOR activity is required for sensory axon regeneration induced by a conditioning lesion. eNeuro 2016 Dec 19. DOI: 10.1523/ENEURO.0358-16.2016 (Epub)
13. Hu W, Yu X, Liu Z, Sun Y, Chen X, Yang X, Li X, Lam WK, Duan Y, Cao X, Steller H, Liu K, Huang P. The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms. eLife. 2017 Jun 28;6. pii: e28021.
14. Lou WPK, Mateos A, Koch M, Klussmann S, Yang C, Lu N, Limpert S, Göpferich M, Zschaetzsch M, Maillo C, Senis E, Grimm D, Méndez R, Liu K, Hassan BA, Martin-Villalba A. Post-transcriptional regulation of adult CNS axonal regeneration by Cpeb1. Frontiers in Molecular Neuroscience, 2018 Jan:10, 445,
15. Weng Y-L, Wang X, Ran A, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong S, Joseph J, Dore L, Dong Q, Zheng W, Jin P, Wu H, Shen B, Zhuang X, He C, Liu K, Song H, Ming G-L. m6A Epitranscriptomic Regulation of Axon Regeneration in the Adult Mammalian Nervous System. Neuron, 2018 Jan:97(2), 313-325. e6
16. Wang G, Zhu H, Situ C, Han L, Yu Y, Cheung TH, Liu K, Wu Z. p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells. EMBO J. 2018 Apr 13;37(8). pii: e98239.