个人简介：欧阳昆富，北京大学学士、博士，美国加州大学圣地亚哥分校博士后、助理研究员，北京大学深圳研究生院教授，北京大学深圳医院心血管外科研究团队课题组长、北京大学医学部研究员、博士生导师。

研究领域：心血管发育与疾病的分子机制研究、钙信号转导、线粒体稳态调控机制

个人学术简介：曾获美国心脏学会Clifford & Evelyn Cherry Fellowship Award、入选北京大学“百人计划”、深圳市“孔雀计划”海外高层次人才B类、深圳市地方级领军人才，中国生理学会理事，《Life Sciences》杂志副主编；参与科技部973项目与国家重点研发计划各1项、主持国自然重大研究计划“培育项目”1项与面上项目4项，深圳市重b点项目1项、深圳市医科院一般项目1项等；迄今为止共发表SCI论文80多篇，总引用（google scholar）超7500次，H-index 38，近年来以通讯/共同通讯作者身份在Circulation、Cell Death Diff、JCI Insight、Circulation: Heart Failure、Cell Death Dis等国际知名杂志上发表多篇研究论文。

主持科研项目：

1.深圳市医学研究专项资金前沿探索型一般项目（B2402022；线粒体蛋白ROMO1的抗氧化机制与心脏保护研究）、2025/01-2027/12、在研、项目负责人

2.国家自然科学基金面上项目（82470245；利用小鼠模型研究线粒体蛋白Dele1调控心脏功能与结构的作用与机制）、2025/01-2028/12、在研、项目负责人

3.科技部国家重点研发计划（2022YFB4600600；功能化活性心肌组织增材制造）、2023/01-2026/12，在研、子课题骨干

4.国家自然科学基金面上项目（82170235；利用心肌细胞特异性PTPMT1基因敲除小鼠研究心磷脂在心脏发育与心脏生理病理过程中的作用）、2022/01-2025/12、在研、项目负责人

5.国家自然科学基金面上项目（81970421；血管平滑肌IP3R调控血管内膜增生与分子机制研究）、2020/01-2023/12、已结题、项目负责人

6.深圳市科技计划基础研究学科布局项目（JCYJ20160428154108239；心力衰竭的线粒体机制研究）、2016/07-2019/06、已结题、项目负责人

7.国家自然科学基金重大研究计划“培育”项目（91439130；蛋白激酶D在血管生成与重构过程中的作用及分子机制）、2015/01-2017/12、已结题、项目负责人

8.国家自然科学基金面上项目（31370823；心肌细胞IP3R在小鼠心脏发育与心肌重塑过程中的作用）、2014/01-2017/12、已结题、项目负责人

9.科技部973项目（2013CB531200；线粒体功能障碍致早期心衰机制及干预策略研究）、2013 /01 -2017/12、已结题、课题骨干

代表性论文：

1.Wang H*, Zhao B*, Huang L*, Zhu X, Li N, Huang C, Han Z#, Ouyang K#. (2024) Conditional deletion of IP3R1 by Islet1-Cre in mice reveals a critical role of IP3R1 in interstitial cells of Cajal in regulating GI motility. J Gastroenterol. doi: 10.1007/s00535-024-02164-1. Online ahead of print.

2.Zhang T*, Bi C*, Li Y, Zhao L, Cui Y, Ouyang K#, Xiao B#. (2024). Phosphorylation of Piezo1 at a single residue, serine-1612, regulates its mechanosensitivity and in vivo mechanotransduction function. Neuron. S0896-6273(24)00581-6. doi: 10.1016/j.neuron.2024.08.009. Online ahead of print.

3.Zhu S*, Chen Z*, Liu C, Duong J, Tran T, Liang Z, Fang X#, Ouyang K#. (2024). The essential role of MED27 in stabilizing the mediator complex for cardiac development and function. Life Sci. 123020. doi: 10.1016/j.lfs.2024.123020. Online ahead of print.

4.Huang F*, Zhang F*, Huang L*, Zhu X, Huang C, Li N, Da Q, Huang Y, Yang H, Wang H, Zhao L, Lin Q, Chen Z, Xu J, Liu J, Ren M, Wang Y#, Han Z#, Ouyang K#. (2024). Inositol 1,4,5-Trisphosphate Receptors Regulate Vascular Smooth Muscle Cell Proliferation and Neointima Formation in Mice. J Am Heart Assoc. e034203. doi: 10.1161/JAHA.124.034203. Online ahead of print.

5.Meng L, Dong R, Mi W, Qin K, Ouyang K#, Sun J#, Li J#. (2024). The ubiquitin E3 ligase APC/CCdc20 mediates mitotic degradation of OGT. J Biol Chem. 107448. doi: 10.1016/j.jbc.2024.107448.

6.Jiang Z, Huang C, Guo E, Zhu X, Li N, Huang Y, Wang P, Shan H, Yin Y, Wang H, Huang L, Han Z, Ouyang K#, Sun L#. (2024) Platelet-Rich Plasma in Young and Elderly Humans Exhibits a Different Proteomic Profile. J Proteome Res. doi: 10.1021/acs.jproteome.4c00030.

7.Shen T, Wang S, Huang C, Zhu S, Zhu X, Li N, Wang H, Huang L, Ren M, Han Z, Ge J#, Chen Z#, Ouyang K#. (2024) Cardiac-specific deletion of heat shock protein 60 induces mitochondrial stress and disrupts heart development in mice. Biochem Biophys Res Commun. 710:149883. doi: 10.1016/j.bbrc.2024.149883.

8.Chen Z, Pan Z, Huang C, Zhu X, Li N, Huynh H, Xu J, Huang L, Vaz FM, Liu J, Han Z#, Ouyang K#. (2024). Cardiac lipidomic profiles in mice undergo changes from fetus to adult. Life Sci. 2:122484. doi: 10.1016/j.lfs.2024.122484. Online ahead of print.

9.Da Q, Huang L, Huang C, Chen Z, Jiang Z, Huang F, Shen T, Sun L, Yan Z, Ye X, Yi J, Huang Y, Da J, Ren M, Liu J, Wang T, Han Z#, Ouyang K#. (2023) Glycolytic regulatory enzyme PFKFB3 as a prognostic and tumor microenvironment biomarker in human cancers. Aging (Albany NY). 15. doi: 10.18632/aging.204758.

10.Jiang Z, Shen T, Huynh H, Fang X, Han Z#, Ouyang K#. (2022) Cardiolipin Regulates Mitochondrial Ultrastructure and Function in Mammalian Cells. Genes. 13, 1889. Doi: 10.3390/genes13101889

11.Tang H#, Li Y, Wang S, Ji J, Zhu X, Bao Y, Huang C, Luo Y, Huang L, Gao Y, Wei C, Liu J, Fang X, Sun L#, Ouyang K#. (2022) IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming. iScience. 25(5):104209. doi: 10.1016/j.isci.2022.104209.

12.Chen Z, Zhu S, Wang H, Wang L, Zhang J, Gu Y, Tan C, Dhanani M, Wever E, Wang X, Xie B, Wang S, Huang L, van Kampen A, Liu J, Han Z, Patel H, Vaz F, Fang X#, Chen J#, Ouyang K#. (2021) PTPMT1 Is Required for Embryonic Cardiac Cardiolipin Biosynthesis to Regulate Mitochondrial Morphogenesis and Heart Development. Circulation. 144(5):403-406. DOI: 10.1161 / CIRCULATIONAHA.121.054768. 

13.Siting Zhu, Ze’e Chen, Mason Zhu, Ying Shen, Leonardo J. Leon, Liguo Chi, Simone Spinozzi, Changming Tan, Yusu Gu, Anh Nguyen, Yi Zhou, Wei Feng, Frédéric M. Vaz, Xiaohong Wang, Asa B. Gustafsson, Sylvia M. Evans, Ouyang Kunfu#, Xi Fang#. (2021) Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy. Circ Heart Fail. 14(6): e008289. (#co-corresponding author)

14.Li Y, Tang H#, Chen F, Chen J, Wang H, Chen Z, Duan Y, Wang X, Li L#, Ouyang K#. (2021) SETD2 is essential for terminal differentiation of erythroblasts during fetal erythropoiesis. Biochem Biophys Res Commun. 552:98-105. doi: 10.1016/j.bbrc.2021.03.040. 

15.Chen Z, Duan Y, Wang H, Tang H, Wang S, Wang X, Liu J, Fang X#, Ouyang K#. (2021) Atypical protein kinase C is essential for embryonic vascular development in mice. Genesis. e23412. doi: 10.1002/dvg.23412.

16.Yang F, Huang L, Tso A, Wang H, Cui L, Lin L, Wang H, Ren M, Fang X, Liu J, Han Z#, Chen J#, Ouyang K#. (2020) Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability. Plos Genetics. 16(4): e1008739. doi: 10.1371/journal.pgen.1008739.

17.Fan F, Duan Y, Yang F, Trexler C, Wang H, Huang L, Li Y, Tang H, Wang G, Fang X, Liu J, Jia N, Chen J#, Ouyang K#. (2020) Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure. Cell Death Diff. 27(2):587-600. doi: 10.1038/s41418-019-0374-x.

18.Duan Y, Wang H, Mitchell-silbaugh K, Cai S, Fan F, Li Y, Tang H, Wang G, Fang X, Liu J, Jia N, Jing R#, Ouyang K#. (2019) Heat shock protein 60 regulates yolk sac erythropoiesis in mice. Cell Death Dis. 10: 766. doi: 10.1038/s41419-019-2014-2.

19.Lin Q, Zhao L, Jing R, Trexler C, Wang H, Li Y, Tang H, Huang F, Zhang F, Fang X, Liu J, Jia N, Chen J#, Ouyang K#. (2019) IP3Rs in endothelial cells play an essential role in vasodilation and blood pressure regulation. J Am Heart Assoc. 8(4): e011704. doi: 10.1161/JAHA.118.011704.

20.Wang H, Jing R, Trexler C, Li Y, Tang H, Pan Z, Zhu S, Zhao B, Fang X, Liu J, Chen J#, Ouyang K#. (2019) Deletion of IP3R1 by Pdgfrb-Cre in mice results in intestinal pseudo-obstruction and lethality. J Gastroenterol. 54(5):407-418. doi: 10.1007/s00535-018-1522-7.

21.Tang H, Wang H, Lin Q, Fan F, Zhang F, Peng X, Fang X, Liu J, Ouyang K#. (2017) Loss of IP3 Receptor–Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function. J Immunol. 199 (2): 570-580; DOI: https://doi.org/10.4049/jimmunol.1700109

22.Lin Q, Zhao G, Fang X, Peng X, Tang H, Wang H, Jing R, Liu J, Lederer WJ, Chen J#, Ouyang K#. (2016) IP3 receptors regulate vascular smooth muscle contractility and hypertension. JCI Insight. 1(17): e89402. doi: 10.1172/jci.insight. 89402.

23.Ouyang K*, Gomez-Amaro R*, Stachura D*, Tang H, Peng X, Fang X, Traver D, Evans SM, Chen J. (2014) Loss of IP3R-mediated Ca2+ signaling in thymocytes leads to aberrant development and acute lymphoblastic leukemia. Nat. Commun. doi: 10.1038/ncomm5814. (*, Co-first author).

24.Cooley N*, Ouyang K*, McMullen JR, Sadoshima J, Kiriasis H, Wu W, Mu Y, Du X, Chen J, Woodcock EA. (2013) No contribution of IP3-R(2) to disease phenotype in models of dilated cardiomyopathy or pressure overload hypertrophy. Circulation: Heart Failure 6: 318-325. (*, Co-first author).

25.Sheikh F*, Ouyang K*, Campbell S*, Lyon R, Chuang J, Fitzsimons D, Tangney J, Hidalgo C, Chung C, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens J, Peterson K, Granzier H, Moss R, McCulloch AD and Chen J. (2012) Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J. Clin. Invest. 122(4): 1209-1221. (*, Co-first author). 

26.Stephan Lange*, Kunfu Ouyang*, Gretchen Meyer, Li Cui, Hongqiang Cheng, Richard L. Lieber, Ju Chen (2009) Obscurin regulates longitudinal SR architecture. J. Cell. Sci. 122: 2640-2650 (*, Co-first Author).

27.Kunfu Ouyang*, Hui Zheng*, Xiaomei Qin, Chen Zhang, Dongmei Yang, Xian Wang, Caihong Wu, Zhuan Zhou & Heping Cheng (2005) Ca2+ sparks and secretion in dorsal root ganglion neurons. Proc. Natl. Acad. Sci. USA 102: 12259-12264 (*, Co-first Author).

联系方式：Tel：13510418022；Email：ouyang_kunfu@pku.edu.cn